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Thank you to all the amazing collaborators, customers, and friends who met with us at ASMS 2023! It’s been a fantastic week full of ExD research and analysis software demos.
This isn't goodbye, it's see you later... hopefully at UPPCON 2023!
— The e-MSion team
From impromptu demos in the bioinformatics hub to one-on-one demos in the Agilent hospitality suite,
our team had a blast sharing ExDViewer with everyone at ASMS!
Sign up for email updates to receive ExDViewer beta releases and important announcements from our team.
New data analysis & visualization software
ExDViewer is designed to meet the challenge of deconvoluting a new data landscape, created by combinations of CID, ECD, ETD, HCD, EThcD, and more collected at the limits of benchtop instrument resolution. Together with our customers, our goal is to make the analysis and visualization of peptide and protein MS/MS data intuitive, adaptable, and widely accessible.
We had four great presenters this year from the e-MSion team!
Oral | Hall B3 MOA | 9:30 am
Adrian Guthals
Parameter-free Deconvolution and Visualization of Peptide and Protein Fragmentation Mass Spectra
Oral | Hall B3 WOA | 3:50pm
Jared Shaw
Protein complex heterogeneity and structure revealed by native mass spectrometry with electron capture charge reduction and surface induced dissociation
June 4, 2023 | Marriott Marquis Houston 1777 Walker St. Houston, TX 77010 Rm: Texas F-G
At the Agilent IM Event on Sunday, ExD user Dr. Blaine Roberts from Emory University discussed: The Hidden Pathophysiology of Lipids and Proteins in Alzheimer’s Revealed with Ion Mobility MS and Quantitative QQQ Biomarker Assays
Be sure to check out all of the new research featuring e-MSion ExD at ASMS!
Access through the ASMS mobile app and online planner.
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Hall B3 MOA 9:30 am
Adrian Guthals
Top Down Protein Analysis
Parameter-free Deconvolution and Visualization of Peptide and Protein Fragmentation Mass Spectra
MP 674
Rachel Franklin
Proteins: PTMs I
Revealing non-canonical phosphorylation of the SARS-CoV-2 nucleocapsid serine/arginine-rich domain using top-down electron capture dissociation and sequence tag generation
Hall B3 MOA 9:50am
Neven Mikawy
Top Down Protein Analysis
Internal Fragment Assignment Challenges in Top-Down Electron Capture Dissociation Tandem Mass Spectrometry
Hall B3 MOA 9:10am
Yuan Gao
Top Down Protein Analysis
Native top-down mass spectrometry approaches to determine the FraB/FrlB-substrate binding sites and conformational changes induced by substrate binding
MP 613
Joaquín Barbeito
Protein Therapeutics: Structural Characterization
Characterization of carbamoylated lysine in a therapeutic recombinant protein top-down electron fragmentation
MP 655
Kristie Baker
Proteins: Conformation Analysis and Structural Biology
Variable-Temperature Electrospray Ionization Coupled with Electron Capture Dissociation to Study Temperature Induced Solution Phase Structural Changes
MP 685
Emma Marsden-Edwards
Proteins: PTMs I
Boosting the sensitivity of electron-based fragmentation with cyclic ion mobility
MP 639
Weijing Liu
Proteins: Conformation Analysis and Structural Biology
Establishing a decision tree for native mass spectrometry analysis of membrane proteins in complex membrane mimetics
MP 653
Melanie Cheung See Kit
Proteins: Conformation Analysis and Structural Biology
Mapping the C-terminus of α-Synuclein conformers by native crosslinking and ion mobility mass spectrometry
Ballroom B 3:50pm
Wonhyeuk Jung
Structural Biology
Direct determination of membrane protein complexes from cellular membranes
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TP 024
Yury V. Vasil'ev
Antibodies & Antibody Drug Conjugates I
Top-down characterization of native monoclonal antibodies obtained with electron capture dissociation on Q-ToF instruments
General assembly A TOF 2:50pm
Aisha Ben-Younis
Ion Mobility: Structure Determination & Applications
Cyclic ion mobility–mass spectrometry and electron capture dissociation probe dimerization of aggregation-prone IAPP
Ballroom B TOC 8:30am
Boyu Zhao
Fundamentals: Native MS and Structures of Large Ions
Native Top-Down MS with Orbitrap-Based Electron Capture Dissociation Reveals Higher Order Structure Information for Protein Complexes
TP 590
Philip Lacey
Proteins: General and Membrane
Electron Capture Charge Reduction Allows for Selection of Individual Nanodisc Species
TP 585
Rachel McAllister
Proteins: General and Membrane
Determining the membrane recruitment mechanisms of peripheral membrane proteins through direct top-down nativeMS analysis from a tunable lipid bilayer
General Assembly A TOF pm 2:30
Ian Webb
Ion Mobility: Structure Determination & Applications
Solution and Gaseous Ensembles of αSynuclein: Towards a Biophysical Understanding of “Unstructured” Protein IM/MS
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Hall B3 WOA 3:50pm
Jared Shaw
Instrumentation: Detection of High-Mass Analytes
Protein complex heterogeneity and structure revealed by native mass spectrometry with electron capture charge reduction and surface induced dissociation
Hall B3 WOA 3:10pm
Kyle I.P. Le Huray
Instrumentation: Detection of High-Mass Analytes
To 200k m/z and beyond: native electron-capture charge reduction resolves heterogeneous signals in large biopharmaceutical analytes, a new Orbitrap record
WP 233
Marius Kostelic
Fundamentals: Formation and Structures of Big Ions
Architecture of Adeno-Associated Viral Capsids with Surface-Induced Dissociation and Charge Detection Mass Spectrometry
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General Assembly A 9:10am
Jessie Le
Protein-Ligand and Protein-Protein Interactions
Native Top-Down Mass Spectrometry Probes Membrane Protein Structures and Lipid Binding Sites
Ballroom A 3:30pm
Benqian Wei
Biotherapeutics: Proteins, Antibodies, and Antibody/Drug Conjugates
Internal Fragments Enhance Middle-down Mass Spectrometry Structural Characterization of Monoclonal Antibodies and Antibody-drug Conjugates
Hall B3 ThOA 3:10pm
Sara Carillo
Instrumentation: Innovative Separation Approaches Coupled to MS
Exploring Charge Detection Mass Spectrometry on Liquid Chromatography Time Scales
General Assembly A ThOF 8:50am
Sophie Harvey
Protein-Ligand and Protein-Protein Interactions
Characterizing the interactions between the HIV-1 capsid protein and small molecule ligands using native mass spectrometry
ThP 588
Blaine Roberts
Peptides: Identification and Fragmentation Mechanisms
Application of electron fragmentation strategies and software for the identification and characterization of iso-aspartate peptides in human tissue
ThP 153
Carter Lantz
Fundamentals: Ion Activation/Dissociation
Digital-Quadrupole Isolation of Native Protein Ions Allows for Interrogation of their Sequence and Structure with Electron Capture Dissociation
ThP 222
Meiby Fernandez Rojas
H/D Exchange: Protein Structure/Function
Integration of HDX and TIMS-q-ExD FT-ICR MS/MS for the Structural Characterization of Native Proteins
ThP 394
