We were thrilled to be back in pre-pandemic form at the 70th Annual American Society for Mass Spectrometry Meeting! Reconnecting with our ExD users and the greater mass spec community was a high point for the team. 

If you couldn’t make it to ASMS this year, check out what you missed here!

We co-hosted our first ever ExD for Thermo Scientific Q Exactive Orbitrap MS user meeting with Zef Scientific! A big thank you to everyone who joined us. If you missed out, check out the event page for recordings of our excellent speakers!

We had three great posters this year from the e-MSion team!

Jared Shaw

Native Top-Down Characterization of Protein Complexes with a Hybrid Electron Capture Dissociation and Surface Induced Dissociation Device

Joseph Meeuwsen

Fine Structural Elucidation of Phospholipids with Practical Electron-Based Fragmentation on Q-TOF Instruments

Rachel Franklin

Investigating Sequential Phosphorylation of the Serine-Arginine-Rich Domain in the SARS-CoV-2 Nucleocapsid using Electron Capture Dissociation

At ASMS, we were excited to see all the ways ExD is being used to advance biomolecule characterization! Here’s a full list of orals and posters featuring e-MSion ExD. Access through September 30, 2022 in the ASMS mobile app and online planner.

ID
TITLE
NAME
TOB 8:30
Adeno-Associated Virus Characterization by SID-CDMS
Vicki Wysocki
TP 157
Electron capture dissociation on a cyclic ion mobility enabled Q-ToF mass spectrometer provides higher structural resolution in HDX-MS experiments
Owen Cornwell
TP 307
Characterization of Protein Structural Changes in the Solution- and Gas-Phases using Electrospray Ionization and Electron Capture Dissociation
Rebecca Cain
TP 313
Structural Characterization of Native Proteins based on HDbX-CIU-TIMS-UVPD-q-ExD-TOF MS/MS
Meiby Fernandez Rojas
TP 359
Fine Structural Elucidation of Phospholipids with Practical Electron-Based Fragmentation on Q-TOF Instruments
Joseph Meeuwsen
TP 426
Bottom-up and Top-down Disulfide Bond Mapping of Beta-lactoglobulin on a Q-TOF with the Capability to Perform both CID and ECD
Rebecca Glaskin
TP 441
Electron-based Fragmentation Methods for the Mapping of Protein Adducts with Benzo[a]pyrene Diol Epoxide
Stanislau Stanisheuski
WOA pm 03:30
Applying Internal Fragments for Top-down and Middle-down Mass Spectrometry of Biotherapeutic (Wednesday, June 8th, 3:30-3:50)
Benqian Wei
WOF 3:50
Native MS and SID reveal that RNA binding lowers the energy required for dissociation of the RNA chaperone HFQ
Chen Du
WP 176
Native Top-Down Characterization of Protein Complexes with a Hybrid Electron Capture Dissociation and Surface Induced Dissociation Device
Jared Shaw
WP 218
Confident O-glycosylation site identification using a cyclic ion mobility – mass spectrometer equipped with ECD functionality
Brad Williams
WP 471
Investigating Sequential Phosphorylation of the Serine-Arginine-Rich domain in the SARS-CoV-2 Nucleocapsid using Electron Capture Dissociation
Rachel Franklin
ThOE 10:10
Antibody Subunit Characterization: Combining ECD and Ion Mobility Separations with Microdroplet Digestion
Christian Klein
ThOA 10:10
A toolkit for characterization of membrane proteins: rapid LC-native MS, I2MS and ECD
Weijing Liu
ThOA 2:30
Top-Down Characterization of Histone H4 Proteoforms using UVPD-TIMS-q-CID/ECD-ToF MS/MS
Kevin Jeanne Dit Fouque
ThP 165
Charge-state Dependent Structural Analysis of α-Synuclein Conformers by Gas-phase Ion/Ion Cross-linking
Melanie Cheung See Kit
ThP 170
Native Top-Down Orbitrap Mass Spectrometry with Electron-Based Dissociation Yields Higher Order Structure Information for Protein Complexes
Joseph Loo
ThP 171
Comprehensive characterization of protein complexes using capillary-electrophoresis mass spectrometry coupled with electron activation and ultraviolet photodissociation
Amanda Helms
ThP 315
Electron capture dissociation and ion mobility of multiply-protonated peptide ions generated by liquid atmospheric pressure MALDI
Jeffery Brown
ThP 489
Benefits of Native Top-Down ECD Fragmentation on a UHMR for the Sequencing of Diverse Immunoglobulin Formats
Kelly Gallagher
ThP 504
Internal Fragmentation Investigation by Electron-Capture Collision-Induced Dissociation of Intact Proteins on a Quadrupole Time-of-Flight Mass Spectrometer
Qianyi Wang

At ASMS, we were excited to see all the ways ExD is being used to advance biomolecule characterization! Here’s a full list of orals and posters featuring e-MSion ExD. Access through September 30, 2022 in the ASMS mobile app and online planner.

TOB 8:30
Vicki Wysocki
Adeno-Associated Virus Characterization by SID-CDMS
TP 313
Meiby Fernandez Rojas
Structural Characterization of Native Proteins based on HDbX-CIU-TIMS-UVPD-q-ExD-TOF MS/MS
TP 307
Rebecca Cain
Characterization of Protein Structural Changes in the Solution- and Gas-Phases using Electrospray Ionization and Electron Capture Dissociation
TP 359
Joseph Meeuwsen
Fine Structural Elucidation of Phospholipids with Practical Electron-Based Fragmentation on Q-TOF Instruments
TP 426
Rebecca Glaskin
Bottom-up and Top-down Disulfide Bond Mapping of Beta-lactoglobulin on a Q-TOF with the Capability to Perform both CID and ECD
TP 441
Stanislau Stanisheuski
Electron-based Fragmentation Methods for the Mapping of Protein Adducts with Benzo[a]pyrene Diol Epoxide
WOA pm 03:30
Benqian Wei
Applying Internal Fragments for Top-down and Middle-down Mass Spectrometry of Biotherapeutic (Wednesday, June 8th, 3:30-3:50)
WOF 3:50
Chen Du
Native MS and SID reveal that RNA binding lowers the energy required for dissociation of the RNA chaperone HFQ
WP 176
Jared Shaw
Native Top-Down Characterization of Protein Complexes with a Hybrid Electron Capture Dissociation and Surface Induced Dissociation Device
WP 218
Brad Williams
Confident O-glycosylation site identification using a cyclic ion mobility – mass spectrometer equipped with ECD functionality
WP 471
Rachel Franklin
Investigating Sequential Phosphorylation of the Serine-Arginine-Rich domain in the SARS-CoV-2 Nucleocapsid using Electron Capture Dissociation
WP 471
Rachel Franklin
Investigating Sequential Phosphorylation of the Serine-Arginine-Rich domain in the SARS-CoV-2 Nucleocapsid using Electron Capture Dissociation
ThOE 10:10
Christian Klein
Antibody Subunit Characterization: Combining ECD and Ion Mobility Separations with Microdroplet Digestion
ThOA 10:10
Weijing Liu
A toolkit for characterization of membrane proteins: rapid LC-native MS, I2MS and ECD
ThOA 2:30
Kevin Jeanne Dit Fouque
Top-Down Characterization of Histone H4 Proteoforms using UVPD-TIMS-q-CID/ECD-ToF MS/MS
ThP 165
Melanie Cheung See Kit
Charge-state Dependent Structural Analysis of α-Synuclein Conformers by Gas-phase Ion/Ion Cross-linking
ThP 170
Joseph Loo
Native Top-Down Orbitrap Mass Spectrometry with Electron-Based Dissociation Yields Higher Order Structure Information for Protein Complexes
ThP 171
Amanda Helms
Comprehensive characterization of protein complexes using capillary-electrophoresis mass spectrometry coupled with electron activation and ultraviolet photodissociation
ThP 315
Jeffery Brown
Electron capture dissociation and ion mobility of multiply-protonated peptide ions generated by liquid atmospheric pressure MALDI
ThP 489
Kelly Gallagher
Benefits of Native Top-Down ECD Fragmentation on a UHMR for the Sequencing of Diverse Immunoglobulin Formats
ThP 504
Qianyi Wang
Internal Fragmentation Investigation by Electron-Capture Collision-Induced Dissociation of Intact Proteins on a Quadrupole Time-of-Flight Mass Spectrometer